J Cell Biochem.2019 Sep;120(9):15989-96
Nonalcoholic fatty liver disease (NAFLD) is a most common liver disease condition that is prevalently seen in one out...
Curr Clin Pharmacol.2017;12(4):253-258
Adipokines such as adiponectin and leptin are known to show anti-inflammatory action along with anti-hyperglycemic actions...
Complement Ther Med.2017 Aug;33:1-5.
People with type 2 diabetes mellitus (T2DM) are known to be at greater risk of cardiovascular diseases such as atherosclerosis...
Curr Pharm Des. 2017;23:1–5
To briefly describe the action of curcumin in regulating the miRNA involved in lung cancer...
Inflammopharmacology.2016. DOI: 10.1007/s10787-016-0301-4
To investigate the antioxidant properties of bioavailability-improved preparations of curcuminoids in diabetic patients...
To evaluate the efficacy of Curcumin C3 Complex® as adjunctive therapy on the eradication of H. pylori infection and severity of dyspepsia in patients with PU...
Biomed Pharmacother. 2016;82:578–82
To evaluate the effect of supplementation with Curcumin C3 Complex® on concentration of serum cytokines in subjects with MetS...
Nutrition.2016, DOI: 10.1016/j.nut.2016.03.018
To evaluate changes in serum levels of adiponectin and leptin, and the ratio of these two adipokines, following Curcumin supplementation in patients with MetS....
J Diet Suppl. 2016; 13(1):93-105
Exposure to Sulphur Mustard (SM) during Iraq-Iran war (1980-88), not only affected the skin but also caused chronic complications in the respiratory system of civilian and army personnel...
J Diet Suppl. 2016; 13(2):209-20
To evaluate the efficacy of Curcumin supplementation in reducing the oxidative stress by measuring the levels of serum concentration of important biomarkers in patients with knee OA...
Iran J Pharm Res. 2015; 14(2):479-486.
To investigate the efficacy of curcumin in subjects with coronary artery disease (CAD) by evaluating lipid profile, blood glucose level and inflammatory markers...
Cancer Lett. 2015; 364(2):135-41.
To assess the safety, tolerability and feasibility of administering oral Curcumin during standard FOLFOX chemotherapy for palliation of colorectal liver metastases...
Trials 2015. DOI: 10.1186/s13063-015-0641-1
This randomized, controlled clinical study will be evaluating the effects of CUFOX (Curcumin and FOLFOX) regimen on the colon cancer subjects...
Chin J Integr Med. 2015; 21(5):332-38
To investigate the antioxidant and anti-inflammatory efficacy of Curcumin on the frequency of symptoms of anxiety and depression in obese individuals...
Clin Nutr. 2015. DOI: 10.1016/j.clnu.2014.12.019
This study was conducted to understand the effect of curcuminoids on systemic oxidative stress and inflammation by measuring superoxide dismutase activity...
J Funct Foods. 2015, DOI: 10.1016/j.jff.2015.01.005
To perform meta-analysis on Curcumin formulations to assess the effect of Curcuminoids supplementation on oxidative stress in health as well as in disease conditions...
Phytother Res. 2015; 29(1):17-21.
Major depressive disorder (MDD) is the most common psychological disorder. The symptoms include irritable mood, disrupted sleep, loss of motivation, decreased concentrating power and even suicidal intentions...
Drug Res. 2015; 65(10):521-25
Osteoarthritis (OA) is a degenerative joint disease associated with inflammation. Inflammatory response activates chondrocytes and synoviocytes to produce matrix degrading enzymes...
Drug Res. 2014. DOI: http://dx.doi.org/10.1055/s-0034-1389986
To investigate effects of Curcuminoids supplementation on markers of pulmonary function and systemic inflammation in SM-intoxicated subjects...
Complement Ther Med. 2014; 22(5):851-57.
To investigate the effects of bioavailability-enhanced Curcuminoids in patients with metabolic syndrome on serum lipid concentration, as an adjunctive to standard of care...
Phytother Res. 2014; 28(5):633-42.
To perform a meta-analysis of clinical trials for investigating the effect of Curcuminoids supplementation on serum CRP concentrations...
Phytother Res. 2014; 28(11):1625-31.
Osteoarthritis (OA) is the most common disease of joints in adults which leads to stiffness of joints, pain and limitation in joint movement. Treatment of OA is challenging due to inefficacy and long...
Sci World J. 2014. DOI: 10.1155/2014/898361
Obesity is a global health problem and its predisposing effects are atherosclerosis, hypertension, type 2 diabetes, and dyslipidemia...
Altern Ther Health Med. 2013; 19(3):21-24.
Oral mucositis (OM), a common consequence of chemotherapy, is caused by inflammation and necrosis of oral mucosa. It has been reported in 40 to 80% of pediatric oncology patients...
Br J Clin Pharmacol. 2013; 75(2):450-62.
Today Curcuminoids have been evaluated for management for several health conditions including Alzheimer’s dementia, cancer and other inflammatory conditions...
Phytother Res. 2013; 27(3):374-9.
Obesity is the major health problem and risk factor for diabetes, dyslipidemia, hyperlipidemia and osteoarthritis...
Phytother Res. 2013; 27(12):1883-8.
Oxidative stress is involved in pathogenesis of atherosclerosis, because of its involvement in oxidation of LDL cholesterol...
Cancer Prev Res. 2013; 6(2):119-128.
In previous studies the pharmacokinetic and pharmacodynamics parameters of Curcumin have been reported but few data is available describing whether methodologies are suitably robust for Curcuminoids...
Radiat Res. 2013; 180(1):34-43.
Radiation dermatitis is the common side effect in 95% of patients receiving radiotherapy for sarcoma or various other types of cancer. Skin is susceptible to damage by ionizing radiation because it is a highly proliferative and self-renewing organ...
J Hematol Malign.2013;3(1):18-23
To study the long term use of Curcumin in two male patients with plasma cell dyscrasias..
Br J Nutr. 2012; 108 (7):1272-9.
Sulfur Mustard [Bis (2-chloroethyl) sulphide] or SM has been used as chemical warfare agent for almost 100 years. SM is a compound with potent alkylating, vesicant, blister-forming, cytotoxic, mutagenic and carcinogenic properties...
Ann Clin Biochem. 2012; 49(Pt 6):580-88.
To investigate the impact of Curcumin on serum inflammatory biomarkers and their association with pruritus severity and QoL...
Int J Pharm Life Sci. 2012; 3(2):1413-23.
Osteoarthritis (OA) or degenerative joint disease is one of the oldest and most common types of arthritis, which leads to breakdown of the joint’s cartilage. This results in rubbing of bones against eachother, causing pain and loss of movement...
J Am Acad Dermatol. 2012; 66(5):752-60.
To evaluate the efficacy, safety and tolerability of Curcuminoids at a dose of 6000 mg/day in patients with OLP...
Phytomedicine 2012; 19(5);418-423.
To summarize long-term open-label use of over the counter (OTC) Curcuminoids i. e. doses,duration and their side effects (including changes in blood count or liver enzymes) in 53 patients with Oral Lichen Planus (OLP) who previously participated in either of the randomized controlled trials of Curcuminoids at UCSF...
Cultivating Natural Bioactives: International Conference July 9 to 11, 2012.
Authors designed a parallel group randomized trial (15 subjects) of schizophrenia with persisted negative symptomsF...
Alzheimers Res Ther. 2012; 4(5):43.
To generate tolerability and preliminary clinical and biomarker efficacy data on Curcumin C3 complex® in persons with mild to moderate AD...
Am J Hematol. 2012; 87(5):455-60.
Monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM) are asymptomatic plasma cell disorders which can progress to multiple myeloma...
Funct Food Health Dis. 2011; 1(12):525-44.
To examine the role of human APE1 in resistance and prognosis in FL patients and to evaluate safety and efficacy of combination of curcumin and epigallocatechin gallate (EGCG) therapy in non-Hodgkin follicular lymphoma patients and their peripheral blood mononuclear cells...
Cancer Chemother Pharmacol. 2011; 68(1):157-64
To conduct Phase I/II study for determining the safety and feasibility of oral Curcumin in combination with gemcitabine-based chemotherapy in patients with pancreatic cancer...
Cancer Prev Res. 2011; 4(3):354-64.
To assess effect of oral administration of Curcumin (a major component of Curcumin C3 complex ®) on PGE2 within ACF, 5-HETE, ACF number and proliferation...
J Oral Sci.
To test the effect of curcumin in patients with leukoplakia, oral submucous fibrosis and lichen planus by measuring serum and salivary levels of MDA, 8-OHdG and Vitamin C, E before and after curcuminoids administration...
Cancer Biol Ther. 2010; 9(1):8-14.
To evaluate the role of Curcumin supplementation on breast cancer patients, who were on Docetaxel (100 mg/m2) regimen.In this open-label, Phase I trial, 14 eligible subjects were enrolled who had metastatic...
Nutr Cancer. 2010; 62(8):1137-41.
To evaluate the activity and feasibility of gemcitabine in combination with Curcumin in patients with advanced pancreatic cancer...
Clin Cancer Res. 2009; 15(18):5917-22.
To determine the effect of Curcumin on plasma cells and osteoclasts in patients with MGUS...
Clin Cancer Res.
To conduct a Phase II study, to determine the biological activity of oral Curcumin in patients with pancreatic cancer...
J Am Acad Dermatol. 2008; 58(4):625-31.
To assess the safety and efficacy of oral Curcumin in the treatment of chronic psoriasis vulgaris..
To evaluate the clinical safety and biologic effects of Curcumin in multiple myeloma (MM) patients who had asymptomatic, relapsed/refractory, or plateau phase disease...
Phytomedicine 2007; 14 (7-8):437-46.
To evaluate the efficacy and safety of Curcuminoids as an adjunct to short-course corticosteroids for the treatment of patients with OLP...
Clin Gastroenterol Hepatol.
To evaluate the efficacy and toxicity of Curcumin-Quercetin combination to regress intestinal adenomas in subjects suffering from FAP...
BMC Complement Altern Med. 2006; 6:10.
To perform a dose escalation study for determining the maximum tolerated dose, safetyprofile, and resultant serum concentration of a single dose of standardized powdered extract (Curcumin C3 Complex ®) obtained from Alleppey finger turmeric...
Cancer Epidemiol Biomarkers Prev. 2005; 14(1):120-25.
To test the hypothesis that pharmacologically active levels of Curcumin can be achieved in colorectum tissue of humans by oral consumption to effect the levels of M1G and COX-2 proteins...
Clin Cancer Res. 2004; 10(20):6847-54.
To analyze toxicity of high doses of Curcumin administered orally to patients with advanced cancer. To investigate the systemic effects of Curcumin consumption...
Br J Cancer. 2004; 90(5):1011-5.
To investigate whether oral administration of Curcumin results in concentrations of the agent in normal and malignant liver tissue, which are sufficient to elicit pharmacological activity...
Planta Med. 1998; 64(4):353-6.
Curcuminoids, despite showing excellent activity in inhibiting the expression of inflammatory cytokines and inhibition of free radicals, due to its low bioavailability and rapid transformation...